Did you know that America’s wild horses are used in extensive fertility control EXPERIMENTS for decades involving forced drugging of PZP, a pesticide made from slaughterhouse pig ovaries on federally protected and state wild horses, field spaying, and more. Which wild horse and humane groups are involved in cruel experimentation that results in killing wild horses to perform necropsies, ripping out ovaries in the field to look for PZP damage, carving up pregnant mares, etc.?
The horse’s reproductive system is very close to a human reproductive system. . .
With many developing countries hungry for long-lasting human contraception, is the pharmaceutical industry being subsidized by tax dollars to fund fertility control experiments on wild horses with the immunocontraceptive PZP and other experimental drugs? Are they cashing in on a cheap laboratory–on the range? As you will read below, the cost to research and develop a new drug is $2.6 billion dollars so follow the money and the decades of PZP and fertility control experiments points to the obvious.
Cost to Develop and Win Marketing Approval for a New Drug Is $2.6 Billion
BOSTON – Nov. 18, 2014 – Developing a new prescription medicine that gains marketing approval, a process often lasting longer than a decade, is estimated to cost $2,558 million, according to a new study by the Tufts Center for the Study of Drug Development.
The $2,558 million figure per approved compound is based on estimated:
Average out-of-pocket cost of $1,395 million
Time costs (expected returns that investors forego while a drug is in development) of $1,163 million
Estimated average cost of post-approval R&D—studies to test new indications, new formulations, new dosage strengths and regimens, and to monitor safety and long-term side effects in patients required by the U.S. Food and Drug Administration as a condition of approval—of $312 million boosts the full product lifecycle cost per approved drug to $2,870 million. All figures are expressed in 2013 dollars.
The new analysis, which updates similar Tufts CSDD analyses, was developed from information provided by 10 pharmaceutical companies on 106 randomly selected drugs that were first tested in human subjects anywhere in the world from 1995 to 2007.
“Drug development remains a costly undertaking despite ongoing efforts across the full spectrum of pharmaceutical and biotech companies to rein in growing R&D costs,” said Joseph A. DiMasi, director of economic analysis at Tufts CSDD and principal investigator for the study.
He added, “Because the R&D process is marked by substantial technical risks, with expenditures incurred for many development projects that fail to result in a marketed product, our estimate links the costs of unsuccessful projects to those that are successful in obtaining marketing approval from regulatory authorities.”
In a study published in 2003, Tufts CSDD estimated the cost per approved new drug to be $802 million (in 2000 dollars) for drugs first tested in human subjects from 1983 to 1994, based on average out-of-pocket costs of $403 million and capital costs of $401 million.
The $802 million, equal to $1,044 million in 2013 dollars, indicates that the cost to develop and win marketing approval for a new drug has increased by 145% between the two study periods, or at a compound annual growth rate of 8.5%.
According to DiMasi, rising drug development costs have been driven mainly by increases in out-of-pocket costs for individual drugs and higher failure rates for drugs tested in human subjects.
Factors that likely have boosted out-of-pocket clinical costs include increased clinical trial complexity, larger clinical trial sizes, higher cost of inputs from the medical sector used for development, greater focus on targeting chronic and degenerative diseases, changes in protocol design to include efforts to gather health technology assessment information, and testing on comparator drugs to accommodate payer demands for comparative effectiveness data.
Lengthening development and approval times were not responsible for driving up development costs, according to DiMasi.
“In fact,” DiMasi said, “changes in the overall time profile for development and regulatory approval phases had a modest moderating effect on the increase in R&D costs. As a result, the time cost share of total cost declined from approximately 50% in previous studies to 45% for this study.”
The study was authored by DiMasi, Henry G. Grabowski of the Duke University Department of Economics, and Ronald W. Hansen at the Simon Business School at the University of Rochester.
ABOUT THE TUFTS CENTER FOR THE STUDY OF DRUG DEVELOPMENT
The Tufts Center for the Study of Drug Development (http://csdd.tufts.edu) at Tufts University provides strategic information to help drug developers, regulators, and policy makers improve the quality and efficiency of pharmaceutical development, review, and utilization. Tufts CSDD, based in Boston, conducts a wide range of in-depth analyses on pharmaceutical issues and hosts symposia, workshops, and public forums, and publishes Tufts CSDD Impact Reports, a bi-monthly newsletter providing analysis and insight into critical drug development issues.
Since wild equines are considered feral pests by the agency mandated to protect them, I wouldn’t be surprised by any insidious plans to harm, maim, or kill our wild ones. Blm violates FRWHBA and ships “protected” wild horses/burros to slaughter, what could be worse? Experiments?
Shame shame what us is up to shame
THE BLM INJECTS OUR WILD HORSES WITH PZP DRUGS< THIS IS ABUSE!!!! THE BLM KEEPS ROUNDING UP WILD HORSES, BLM IS RIPPING APART WILD HORSES FAMILIES!! THE BLM CHASES OUR WILD HORSES WITH HELICOPTER'S!!! THE BLM SHOT MANY OF OUR WILD HORSES IN THEIR HEAD!! THE BLM KICKS AND PULLS OUR WILD HORSES BY THEIR TAILS, ABUSE!! BLM CHASES WILD HORSES IN DANGEROUS TEMPERATURES, THIS IS ABUSE!! BLM HAS BEEN CAUGHT SELLING OUR WILD HORSES FOR SLAUGHTER!!!! THE BLM HAS CUT THE LEGS OF OUR BABY FOALS!!! THE BLM HELICOPTER'S BULLY OUR WILD HORSES WITH THEIR HELICOPTER'S, EVEN THE LITTLE BABY FOALS, NOW THAT IS VERY SICK & ABUSIVE!!!!! THE BLM CHASES OUR WILD PREGNANT MARES WHICH FORCES THEM TO ABORT THEIR FOALS , YOU SEE THE BLM DOES NOT WANT THE BABY FOALS, THEY'D RATHER THEIR MOTHERS ABORT THEM, SO THE BLM DOES NOT TO HAVE TO SEPARATE THEM AFTER THE ROUNDUPS!! THE BLM DOES NOT CARE ABOUT THE ELDERLY WILD HORSES, THEY JUST RUN THEM TO DEATH OR SEND THEM TO SLAUGHTER!!!!!!!!!!!!!!!!!
THE BLM WOULD RATHER HAVE ALL THE BABY FOALS DEAD AND ALSO HAVE THE YOUNGER FOALS TRAMPLED BY THEIR OWN FAMILIES DURING THE HORRIFYING BLM ROUNDUPS!!!!!! STOP THE BLM RIGHT NOW!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! TINA WOOTEN 4 WILD HORSES!!!!!!!!!
The wild horses and burros are almost extinct on our ranges where long ago they stood as an American symbol of freedom. Where did they all go? Where do they stand today? I cannot believe the sterilation and testing being done on them today will not be tried on you and I someday. Don’t let them get away with this genocide speak up now!
The experimentation on wild horses is right out of a Mary Shelley novel. The goal is non surgical sterilization so they can rid our public lands of native wild horses for their own greedy intentions. Of course, we taxpaying citizens are left to pay the tab. The BLM and the PZP pushing, false advocates are all getting a good chunk of change for this travesty.
This is definitely a real possibility. In fact I feel it should be looked into by the FDA.
This would be terrible as they are probably shipped to slaughter with this PZP running through their bodies. So much could go wrong if they are using open range for laboratories. GOD forbid.
This is a distince possibility for this vaccine. One must not be fooled but look to the motivations of people and how they often thoughtlessly use and abuse horses after putting their moral blinders on.
So now, just like other animals, we would run tests on them. OH, humanity’s horrors never end!!!! Well, you evil bastards, we here at Protect Mustangs will not stop until you pay for your crimes against nature and the American people you sick, little evil scumbags of shit assholes!!!!!
(Excuse my French)
Immunocontraception experimentation on wildlife is foolish, there is no way that data can be collected and valid studies can be conducted. One can only presume that the intent is to destroy the wildlife populations in question. And by the way, PZP is a pesticide, both the manufacturer and the EPA say so.
what a shame….poor innocent horses…………
shame on all of you, God is watching you.